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KMID : 0811720030070000180
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Korean Journal of Physiology & Pharmacology
2003 Volume.7 No. 0 p.180 ~ p.0
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Effects of GB21 Herbal Acupuncture (Cnidium officinale) on Forcal Ischemia Induced by Inserted Intraluminal Filament in MCA of Rats
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Youn Dae-Hwan
Choi Dong-Hee
Lee You-Kyong
Na Chang-Soo
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Abstract
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Cnidium officinale(CO) has been used for activation of blood flow and nourishing of the blood in the Oriental Medicine. So this study was planned to investigate the effects of CO Herbal acupuncture on central cholinergic system induced by the focal ischemia in Sprague Dawley rat. We induced forcal ischemia for 2 hours and herbal acupuncture at GB21 (Kyonjeong) was daily proceeded for 7 days after induction
The ischemic injury degenerated density of acethlcholinesterase (AchE)-immunoreactivity and neuronal cell (by cresyl violet stanining method) in the hippocampal CA1, CA3 (fields CA1-3 of Ammon’s horn). The density of AchE in the hippocampal CA1 was significantly increased in CO-1 group (0.0825 g/kg) compared to negative control group. The density of neuronal cell was significantly increased in CO-1, CO-2 groups compared to negative and positive control group. Our studies suggest an evidence of GB21 herbal acupuncture (Cnidium officinale) as treatment for the early stroke.
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KEYWORD
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herbal acupuncture, MCA, Cnidium officinale, AchE, Cresyl violet
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